Histological grading in breast cancer.
نویسندگان
چکیده
منابع مشابه
Quality control for histological grading in breast cancer: an Italian experience.
Although the diagnostic criteria for histological grading in breast cancer have been improved by the introduction of the Nottingham/Tenovus classification, good results in terms of reproducibility are hard to obtain. The objective of this study was to validate a methodological protocol for external quality control. We assessed the intra- and interlaboratory reproducibility for grading score and...
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Tumour progression is currently believed to result from genetic instability. Chromosomal patterns specific of a type of cancer are frequent even though phenotypic spatial heterogeneity is omnipresent. The latter is the usual cause of histological grading imprecision, a well documented problem, without any fully satisfactory solution up to now. The present article addresses this problem in breas...
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labelling.' PCNA immunohistochemical expression (evaluated with the PCI0 mono-clonal antibody) seems to be related to cellular proliferation in many normal tissues and in some neoplasms,2 such as gastro-intestinal lymphomas,3 central nervous system tumours,4 lung neuroendocrine neoplasms,' and prostatic carcinomas.' However, in other tumours, like breast and gastric cancer, PCNA (PC 10) express...
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Poor histological differentiation is currently considered among the adverse histopathological factors associated with unfavourable clinical course of colorectal carcinoma (CRC). At present, the histological grade of CRC is assessed based on the percentage of glandular differentiation in the tumor according to the World Health Organization (WHO) criteria. However the prognostic value of the WHO ...
متن کاملHistological grading of breast cancer on needle core biopsy: the role of immunohistochemical assessment of proliferation
AIMS Histological grade assessed on needle core biopsy (NCB) moderately concurs with the grade in the surgical excision specimen (SES) (kappa-values between 0.35 and 0.65). A major cause of the discrepancy is underestimation of mitoses in the NCB specimen. The aim was to determine the best method of assessing proliferation on NCB. METHODS AND RESULTS Proliferative activity of 101 invasive car...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 1969
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.1969.39